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Scientific article
Open access
English

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

Publication date2015-03-30
First online date2015-03-30
Abstract

The development of an embryo from a single fertilized cell is orchestrated by a large set of key regulatory genes whose activities need to be precisely controlled. Proteins from the Polycomb group (PcG) family maintain the inactive state of these genes by modifying the surrounding histone H3 tails. Here we report that these inactive genes contact other PcG-rich regions within otherwise active environments in the cell nucleus, suggesting the presence of repressive microenvironments. PcG positive genes interact independently from neighboring genes, depending on their linear distance and more global chromosome folding characteristics, with only moderate changes during embryonic development.

eng
Keywords
  • Hox genes
  • Polycomb
  • Long-range chromatin contacts
  • Nuclear organization
Funding
Citation (ISO format)
VIEUX-ROCHAS, Maxence et al. Clustering of mammalian <i>Hox</i> genes with other H3K27me3 targets within an active nuclear domain. In: Proceedings of the National Academy of Sciences of the United States of America, 2015, vol. 112, n° 15, p. 4672–4677. doi: 10.1073/pnas.1504783112
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Article (Published version)
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Identifiers
ISSN of the journal0027-8424
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