Scientific article
Open access

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

Publication date2015-03-30
First online date2015-03-30

The development of an embryo from a single fertilized cell is orchestrated by a large set of key regulatory genes whose activities need to be precisely controlled. Proteins from the Polycomb group (PcG) family maintain the inactive state of these genes by modifying the surrounding histone H3 tails. Here we report that these inactive genes contact other PcG-rich regions within otherwise active environments in the cell nucleus, suggesting the presence of repressive microenvironments. PcG positive genes interact independently from neighboring genes, depending on their linear distance and more global chromosome folding characteristics, with only moderate changes during embryonic development.

  • Hox genes
  • Polycomb
  • Long-range chromatin contacts
  • Nuclear organization
Citation (ISO format)
VIEUX-ROCHAS, Maxence et al. Clustering of mammalian <i>Hox</i> genes with other H3K27me3 targets within an active nuclear domain. In: Proceedings of the National Academy of Sciences of the United States of America, 2015, vol. 112, n° 15, p. 4672–4677. doi: 10.1073/pnas.1504783112
Main files (1)
Article (Published version)
ISSN of the journal0027-8424

Technical informations

Creation04/05/2024 12:37:08 PM
First validation04/30/2024 9:25:31 AM
Update time04/30/2024 9:25:31 AM
Status update04/30/2024 9:25:31 AM
Last indexation05/06/2024 6:29:29 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack