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Scientific article
Open access
English

Characterization of paralogous uncx transcription factor encoding genes in zebrafish

Published inGene, vol. 721, no. Supplement, 100011
Publication date2019-03-20
First online date2019-03-08
Abstract

The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning that zebrafish genes uncx4.1 and uncx are orthologs of mouse Uncx, we studied their genomic environment and developmental expression. Evolutionary analyses indicate the zebrafish uncx genes as being paralogs deriving from teleost-specific whole-genome duplication. Whole-mount in situ mRNA hybridization of uncx transcripts in zebrafish embryos reveals novel expression domains, confirms those previously known, and suggests sub-functionalization of paralogs. Using genetic mutants and pharmacological inhibitors, we investigate the role of signaling pathways on the expression of zebrafish uncx genes in developing somites. In identifying putative functional role(s) of zebrafish uncx genes, we hypothesized that they encode transcription factors that coordinate growth and innervation of somitic muscles.

eng
Keywords
  • Uncx
  • TSGD
  • Zebrafish
  • Synteny
  • Signaling pathway
  • Development
Citation (ISO format)
NITTOLI, Valeria et al. Characterization of paralogous <i>uncx</i> transcription factor encoding genes in zebrafish. In: Gene, 2019, vol. 721, p. 100011. doi: 10.1016/j.gene.2019.100011
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ISSN of the journal0378-1119
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