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Scientific article
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English

Chromatin organization and global regulation of Hox gene clusters

Published inPhilosophical transactions - Royal Society. Biological sciences, vol. 368, no. 1620, 20120367
Publication date2013-06-19
First online date2013-06-19
Abstract

During development, a properly coordinated expression of Hox genes, within their different genomic clusters is critical for patterning the body plans of many animals with a bilateral symmetry. The fascinating correspondence between the topological organization of Hox clusters and their transcriptional activation in space and time has served as a paradigm for understanding the relationships between genome structure and function. Here, we review some recent observations, which revealed highly dynamic changes in the structure of chromatin at Hox clusters, in parallel with their activation during embryonic development. We discuss the relevance of these findings for our understanding of large-scale gene regulation.

eng
Keywords
  • Chromatin architecture
  • Collinearity
  • Embryonic patterning
  • Long-range regulation
  • Nuclear organization
Citation (ISO format)
MONTAVON, Thomas, DUBOULE, Denis. Chromatin organization and global regulation of <i>Hox</i> gene clusters. In: Philosophical transactions - Royal Society. Biological sciences, 2013, vol. 368, n° 1620, p. 20120367. doi: 10.1098/rstb.2012.0367
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ISSN of the journal0962-8436
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