Scientific article

Molecular and environmental determinants of biomolecular condensate formation

Published inNature chemical biology, vol. 18, no. 12, p. 1319-1329
Publication date2022-11-18
First online date2022-11-18

Biomolecular condensate formation has been implicated in a host of biological processes and has found relevance in biology and disease. Understanding the physical principles and underlying characteristics of how these macromolecular assemblies form and are regulated has become a central focus of the field. In this Review, we introduce features of phase-separating biomolecules from a general physical viewpoint and highlight how molecular features, including affinity, valence and a competition between inter- and intramolecular contacts, affect phase separation. We then discuss sequence properties of proteins that serve to mediate intermolecular interactions. Finally, we review how the intracellular environment can affect structural and sequence determinants of proteins and modulate physical parameters of their phase transitions. The works reviewed highlight that a complex interplay exists between structure, sequence and environmental determinants in the formation of biomolecular condensates.

Affiliation Not a UNIGE publication
Citation (ISO format)
VILLEGAS, José A., HEIDENREICH, Meta, LEVY, Emmanuel. Molecular and environmental determinants of biomolecular condensate formation. In: Nature chemical biology, 2022, vol. 18, n° 12, p. 1319–1329. doi: 10.1038/s41589-022-01175-4
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Article (Published version)
ISSN of the journal1552-4450

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