Article scientifique
Accès libre

Mammalian-specific ectodermal enhancers control the expression of hoxc genes in developing nails and hair follicles

Date de publication2020-11-16
Date de mise en ligne2020-11-16

In this study, we report a unique and necessary function for the HoxC gene cluster in the development of some ectodermal organs, as illustrated both by the hair and nail phenotype displayed by mice lacking the Hoxc13 function and by the congenital anonychia (absence of nails) in full HoxC cluster mutants. We show that Hoxc genes are activated in a colinear manner in the embryonic limb ectoderm and are subsequently transcribed in developing nails and hairs. We identify two mammalian-specific enhancers located upstream of the HoxC cluster, which display an exclusive ectodermal specificity. Individual or combined enhancer deletions suggest that they act in combination to raise the transcription level of several Hoxc genes during hair and nail development.

  • Hox genes
  • Enhancers
  • Hair follicles
  • Nails
  • Transcription
Citation (format ISO)
FERNANDEZ-GUERRERO, Marc et al. Mammalian-specific ectodermal enhancers control the expression of <i>hoxc</i> genes in developing nails and hair follicles. In: Proceedings of the National Academy of Sciences of the United States of America, 2020, vol. 117, n° 48, p. 30509–30519. doi: 10.1073/pnas.2011078117
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Article (Published version)
ISSN du journal0027-8424

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Première validation23/04/2024 12:53:36
Heure de mise à jour23/04/2024 12:53:36
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