The COVID-19 pandemic has caused disruptions in many aspects of daily life. Healthcare workers and students were particularly affected since they had to face a yet-unknown lethal disease without being able to attend regular and continuous education sessions. This Privat-Docent thesis is based on five studies assessing the impact of innovative and highly interactive web-based or blended education interventions on knowledge and skill acquisition, and, when relevant, on infection prevention behavior. All these trials were designed according to the checklist for reporting results of internet e-surveys, better known as its acronym, CHERRIES. Since all but one of these trials were randomized, the eHealth extension of the consolidated standards of reporting trials was consistently used and methods and results reported accordingly. Several perspectives can be drawn from these five trials and are detailed at the end of this thesis, including the importance of a collaborative, interprofessional and trans-departmental approach.