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A systematic review on the excess health risk of antibiotic-resistant bloodstream infections for six key pathogens in Europe

Published inClinical microbiology and infection, p. S1198-1743X(23)00419-6
Publication date2023-10-04
First online date2023-10-04
Abstract

Background: Antimicrobial resistance is a global threat, which requires novel intervention strategies, for which priority pathogens and settings need to be determined.

Objectives: We evaluated pathogen-specific excess health burden of drug-resistant bloodstream infections (BSIs) in Europe.

Methods: A systematic review and meta-analysis.

Data sources: MEDLINE, Embase, and grey literature for the period January 1990 to May 2022.

Study eligibility criteria: Studies that reported burden data for six key drug-resistant pathogens: carbapenem-resistant (CR) Pseudomonas aeruginosa and Acinetobacter baumannii, third-generation cephalosporin or CR Escherichia coli and Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium. Excess health outcomes compared with drug-susceptible BSIs or uninfected patients. For MRSA and third-generation cephalosporin E. coli and K. pneumoniae BSIs, five or more European studies were identified. For all others, the search was extended to high-income countries.

Participants: Paediatric and adult patients diagnosed with drug-resistant BSI.

Interventions: Not applicable.

Assessment of risk of bias: An adapted version of the Joanna-Briggs Institute assessment tool.

Methods of data synthesis: Random-effect models were used to pool pathogen-specific burden estimates.

Results: We screened 7154 titles, 1078 full-texts and found 56 studies on BSIs. Most studies compared outcomes of drug-resistant to drug-susceptible BSIs (46/56, 82.1%), and reported mortality (55/56 studies, 98.6%). The pooled crude estimate for excess all-cause mortality of drug-resistant versus drug-susceptible BSIs ranged from OR 1.31 (95% CI 1.03-1.68) for CR P. aeruginosa to OR 3.44 (95% CI 1.62-7.32) for CR K. pneumoniae. Pooled crude estimates comparing mortality to uninfected patients were available for vancomycin-resistant Enterococcus and MRSA BSIs (OR of 11.19 [95% CI 6.92-18.09] and OR 6.18 [95% CI 2.10-18.17], respectively).

Conclusions: Drug-resistant BSIs are associated with increased mortality, with the magnitude of the effect influenced by pathogen type and comparator. Future research should address crucial knowledge gaps in pathogen- and infection-specific burdens to guide development of novel interventions.

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Keywords
  • Antimicrobial resistance
  • Bloodstream infections
  • Burden
  • Health outcomes
  • Health technology
  • Mortality
Citation (ISO format)
HASSOUN-KHEIR, Nasreen et al. A systematic review on the excess health risk of antibiotic-resistant bloodstream infections for six key pathogens in Europe. In: Clinical microbiology and infection, 2023, p. S1198–1743X(23)00419–6. doi: 10.1016/j.cmi.2023.09.001
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Identifiers
ISSN of the journal1198-743X
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