Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing

Andrianarivelo, Njiva Andry; Saint-Jour, Estefani; Pousinha, Paula; Fernandez, Sebastian P.; Petitbon, Anna; De Smedt-Peyrusse, Veronique; Heck, Nicolas; Ortiz, Vanesa; Allichon, Marie-Charlotte; Kappès, Vincent; Betuing, Sandrine; Walle, Roman; Zhu, Ying; Joséphine, Charlène; Bemelmans, Alexis-Pierre; Turecki, Gustavo; Mechawar, Naguib; Javitch, Jonathan A.; Caboche, Jocelyne; Trifilieff, Pierre; Barik, Jacques; Vanhoutte, Peter

doi:10.1126/sciadv.abg5970

Scientific article

English

Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing

Published inScience advances, vol. 7, no. 43, eabg5970

Publication date2021-10-22

Abstract

D2R-NMDAR receptor heteromers are potential therapeutic targets in drug addiction.

Affiliation entities

Not a UNIGE publication

Research groups

Les dysfonctions synaptiques du cerveau (971)

Citation (ISO format)

ANDRIANARIVELO, Njiva Andry et al. Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing. In: Science advances, 2021, vol. 7, n° 43, p. eabg5970. doi: 10.1126/sciadv.abg5970

Article (Published version)

CC BY-NC-4.0

Identifiers

PID : unige:175337
DOI : 10.1126/sciadv.abg5970
PMID : 34669474
PMCID : PMC8528421

Additional URL for this publicationhttps://www.science.org/doi/10.1126/sciadv.abg5970

Journal ISSN2375-2548

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Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing

D2R-NMDAR receptor heteromers are potential therapeutic targets in drug addiction.

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