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Role of Oxidative Stress and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Nonalcoholic Fatty Liver Disease

Published inInternational journal of molecular sciences, vol. 24, no. 14, 11271
Publication date2023-07-10
First online date2023-07-10
Abstract

Nonalcoholic fatty liver disease (NAFLD) has become a widely studied subject due to its increasing prevalence and links to diseases such as type 2 diabetes and obesity. It has severe complications, including nonalcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma, and portal hypertension that can lead to liver transplantation in some cases. To better prevent and treat this pathology, it is important to understand its underlying physiology. Here, we identify two main factors that play a crucial role in the pathophysiology of NAFLD: oxidative stress and the key role of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). We discuss the pathophysiology linking these factors to NAFLD pathophysiology.

eng
Keywords
  • CEACAM1
  • NAFLD
  • NASH
  • Diabetes
  • Insulin resistance
  • Oxidative stress
Citation (ISO format)
MEMAJ, Plator, OUZERARA, Zayd, JORNAYVAZ, François. Role of Oxidative Stress and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Nonalcoholic Fatty Liver Disease. In: International journal of molecular sciences, 2023, vol. 24, n° 14, p. 11271. doi: 10.3390/ijms241411271
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ISSN of the journal1422-0067
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