Role of Oxidative Stress and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Nonalcoholic Fatty Liver Disease

Article Article scientifique Revue de la littérature Role of Oxidative Stress and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Nonalcoholic Fatty Liver Disease eng 2023-07-10 2023-07-10 author Memaj Plator 808915 author Ouzerara Zayd 780741 author Jornayvaz François 0000-0001-9425-3137 641037 Département de médecine (DEMED) 11271 10.3390/ijms241411271 37511031 1422-0067 PMC10379080 https://www.mdpi.com/1422-0067/24/14/11271 <p>Nonalcoholic fatty liver disease (NAFLD) has become a widely studied subject due to its increasing prevalence and links to diseases such as type 2 diabetes and obesity. It has severe complications, including nonalcoholic steatohepatitis, cirrhosis, hepatocellular carcinoma, and portal hypertension that can lead to liver transplantation in some cases. To better prevent and treat this pathology, it is important to understand its underlying physiology. Here, we identify two main factors that play a crucial role in the pathophysiology of NAFLD: oxidative stress and the key role of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). We discuss the pathophysiology linking these factors to NAFLD pathophysiology.</p> CEACAM1 NAFLD NASH Diabetes Insulin resistance Oxidative stress Dewey 612 Dewey 616 56 Département de médecine 221 134 Département de physiologie cellulaire et métabolisme 21C false 1263 MASLD/MASH et résistance à l'insuline 997 International journal of molecular sciences 24 14 823edd8c-9975-4bea-9e76-0be35cf0b250 Article (Published version) Public Article-scientifique-from-unpaywall.pdf 969304 application/pdf CC BY-4.0 8260b23abcfc6f2a86deb47561c431c6c79235f46b2baf0a0c4d07d3932aac2f openAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

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Role of Oxidative Stress and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 in Nonalcoholic Fatty Liver Disease	International journal of molecular sciences			2023	72	21

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Ouzerara, Zayd