Scientific article

Remodeling Collapsed DNA Replication Forks for Cancer Development

Published inCancer research, vol. 79, no. 7, p. 1297-1298
Publication date2019-04-01
First online date2019-04-01

DNA replication stress is prevalent in human cancers, but absent in normal cells, suggesting that proteins involved in the cellular response to DNA replication stress could be potential therapeutic targets. SMARCAL1 and ZRANB3 are annealing helicases that mediate the repair of collapsed DNA replication forks. In a study in this issue of Cancer Research, Puccetti and colleagues report that mice lacking either SMARCAL1 or ZRANB3 activity have delayed development of MYC-induced B-cell lymphomas. Thus, inhibiting the response to DNA replication stress could benefit patients with cancer.

Citation (ISO format)
SOTIRIOU, Sotirios, HALAZONETIS, Thanos. Remodeling Collapsed DNA Replication Forks for Cancer Development. In: Cancer research, 2019, vol. 79, n° 7, p. 1297–1298. doi: 10.1158/0008-5472.CAN-19-0216
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Article (Published version)
ISSN of the journal0008-5472

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