The advent of computed tomodensitometry has led to an increase in the incidence rate of subsegmental pulmonary embolism. The clinical implications of this category of pulmonary embolism remain unclear up to now, to the point that some experts question the indication for therapeutic anticoagulation. The purpose of this article is to review the existing literature regarding the management of subsegmental pulmonary embolism and to propose a pragmatic approach regarding the indication for therapeutic anticoagulation.