Targeted mupirocin-based decolonization for <i>Staphylococcus aureus</i> carriers and the subsequent risk of mupirocin resistance in haemodialysis patients - a longitudinal study over 20 years

Hassoun-Kheir, Nasreen; Buetti, Niccolo; Olivier, Valérie; Perez, Francine Monique; Frossard, Jean-Louis; Renzi, Gesuele; Schrenzel, Jacques; Saudan, Patrick; Harbarth, Stéphan Juergen

doi:10.1016/j.jhin.2023.01.019

Scientific article

English

Targeted mupirocin-based decolonization for Staphylococcus aureus carriers and the subsequent risk of mupirocin resistance in haemodialysis patients - a longitudinal study over 20 years

Errata

An error was discovered in the results reported in the original article. After the correction, the observed and modelled incidence of bloodstream infections due to S. aureus were updated in the following text under "Results and discussion” and in the supplementary file. Figure 2 was updated accordingly. Yet the main conclusions of the study remain unaffected.
DOI : 10.1016/j.jhin.2024.12.007
PMID : 39799093

ContributorsHassoun-Kheir, Nasreen; Buetti, Niccolo; Olivier, Valérie

; Perez, Francine Monique; Frossard, Jean-Louis; Renzi, Gesuele; Schrenzel, Jacques; Saudan, Patrick; Harbarth, Stéphan Juergen

Published inThe Journal of hospital infection, vol. 135, p. 55-58

Publication date2023-05

First online date2023-02-16

Abstract

Mupirocin-based decolonization of Staphylococcus aureus carriers undergoing haemodialysis is not widely implemented due to concerns of mupirocin resistance. In our haemodialysis unit, a strategy combining universal S. aureus screening with targeted mupirocin-based decolonization was introduced two decades ago. In this study of haemodialysis patients, mupirocin resistance was assessed in blood and colonizing S. aureus isolates during two periods. Mupirocin resistance in S. aureus was infrequent in both blood and colonizing isolates. Furthermore, in the years 2003-2021, a decreasing trend in the annual rate of S. aureus bloodstream infections was observed. Targeted mupirocin-based decolonization of S. aureus carriers undergoing haemodialysis is a sustainable measure for preventing healthcare-associated infections.

Keywords

Bloodstream infections
Haemodialysis
Mupirocin resistance
Staphylococcal carriage
Humans
Mupirocin / therapeutic use
Staphylococcus aureus
Longitudinal Studies
Chlorhexidine
Carrier State / drug therapy
Staphylococcal Infections / drug therapy
Staphylococcal Infections / prevention & control
Renal Dialysis / adverse effects
Anti-Bacterial Agents / therapeutic use

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Funding

European Commission - Predicting the Impact of Monoclonal Antibodies & Vaccines on Antimicrobial Resistance [101034420]

Citation (ISO format)

HASSOUN-KHEIR, Nasreen et al. Targeted mupirocin-based decolonization for Staphylococcus aureus carriers and the subsequent risk of mupirocin resistance in haemodialysis patients - a longitudinal study over 20 years. In: The Journal of hospital infection, 2023, vol. 135, p. 55–58. doi: 10.1016/j.jhin.2023.01.019