Scientific article

Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex

Published inMechanisms of development, vol. 54, no. 1, p. 9-21
Publication date1996-01

In tetrapods, Hox genes are essential for the proper organization and development of axial structures. Experiments involving Hox gene inactivations have revealed their particularly important functions in the establishment of morphological transitions within metameric series such as the vertebral column. Teleost fish show a much simpler range of axial (trunk or appendicular) morphologies, which prompted us to investigate the nature of the Hox system in these lower vertebrates. Here, we show that fish have a family of Hox genes, very similar in both number and general organization, to that of tetrapods. Expression studies, carried out with HoxD and HoxA genes, showed that all vertebrates use the same general scheme, involving the colinear activation of gene expression in both space and time. Comparisons between tetrapods and fish allowed us to propose a model which accounts for the primary function of this gene family. In this model, a few ancestral Hox genes were involved in the determination of polarity in the digestive tract and were further recruited in more elaborate axial structures.

  • Hox genes
  • Tetrapods
  • Fish
  • HOXD complex
Citation (ISO format)
VAN DER HOEVEN, Franciscus Albertus et al. Teleost <i>HoxD</i> and <i>HoxA</i> genes: comparison with tetrapods and functional evolution of the <i>HOXD</i> complex. In: Mechanisms of development, 1996, vol. 54, n° 1, p. 9–21. doi: 10.1016/0925-4773(95)00455-6
Main files (1)
Article (Published version)
ISSN of the journal0925-4773

Technical informations

Creation09/06/2023 12:53:28 PM
First validation09/08/2023 8:08:59 AM
Update time09/08/2023 8:08:59 AM
Status update09/08/2023 8:08:59 AM
Last indexation01/18/2024 12:47:34 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack