Extending the contacts breaks the flow

Carreras Sureda, Amado; Henry, Christopher; Demaurex, Nicolas

doi:10.1177/25152564221125045

Scientific article

Comment

English

Extending the contacts breaks the flow

ContributorsCarreras Sureda, Amado

; Henry, Christopher

; Demaurex, Nicolas

Published inContact, vol. 6, 25152564221125045

Publication date2023

First online date2023-01-11

Abstract

In this news and views, we discuss our recent publication where we described how ER-PM membrane contact sites (MCS) are modulated during store operated calcium entry (SOCE). We also examine why enforcing ER-PM MCS by tethering proteins does not not enhance, but rather inhibits SOCE.

Keywords

Electron microscopy
Endoplasmic reticulum
Plasma membrane
Store-operated calcium entry (SOCE) (SOC)
Tether

NoteRegarding : HENRY, Christopher, CARRERAS SUREDA, Amado, DEMAUREX, Nicolas. Enforced tethering elongates the cortical endoplasmic reticulum and limits store-operated calcium entry. In: Journal of cell science, 2022, 135(6):jcs259313 (https://archive-ouverte.unige.ch/unige:159487)

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Research groups

Signaux intracellulaires (210)

Funding

Swiss National Science Foundation - Calcium signaling at membrane contact sites during phagocytosis [189042]

Citation (ISO format)

CARRERAS SUREDA, Amado, HENRY, Christopher, DEMAUREX, Nicolas. Extending the contacts breaks the flow. In: Contact, 2023, vol. 6, p. 25152564221125045. doi: 10.1177/25152564221125045