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Scientific article
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Advanced in vitro models for renal cell carcinoma therapy design

Published inBiochimica et biophysica acta, CR. Reviews on cancer, vol. 1878, no. 5, p. 188942
Publication date2023-09
First online date2023-06-19
Abstract

Renal cell carcinoma (RCC) and its principal subtype, clear cell RCC, are the most diagnosed kidney cancer. Despite substantial improvement over the last decades, current pharmacological intervention still fails to achieve long-term therapeutic success. RCC is characterized by a high intra- and inter-tumoral heterogeneity and is heavily influenced by the crosstalk of the cells composing the tumor microenvironment, such as cancerassociated fibroblasts, endothelial cells and immune cells. Moreover, multiple physicochemical properties such as pH, interstitial pressure or oxygenation may also play an important role. These elements are often poorly recapitulated in in vitro models used for drug development. This inadequate recapitulation of the tumor is partially responsible for the current lack of an effective and curative treatment. Therefore, there are needs for more complex in vitro or ex vivo drug screening models. In this review, we discuss the current state-of-the-art of RCC models and suggest strategies for their further development.

eng
Keywords
  • Angiogenesis
  • Cancer-associated fibroblasts
  • Organoids
  • Microfluidic device
  • Organ-on-chip
  • Renal cell carcinoma
  • Tumor microenvironment
  • Screening platform
  • Hypoxia
  • Immune system
Citation (ISO format)
MIEVILLE, Valentin et al. Advanced in vitro models for renal cell carcinoma therapy design. In: Biochimica et biophysica acta, CR. Reviews on cancer, 2023, vol. 1878, n° 5, p. 188942. doi: 10.1016/j.bbcan.2023.188942
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ISSN of the journal0304-419X
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Creation06/23/2023 10:12:11 AM
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