Scientific article
OA Policy
English

Correlation between Pulmonary Artery Pressure and Vortex Duration Determined by 4D Flow MRI in Main Pulmonary Artery in Patients with Suspicion of Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Published inJournal of clinical medicine, vol. 11, no. 17, 5237
Publication date2022-09-05
First online date2022-09-05
Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the causes of pulmonary hypertension (PH) and requires invasive measurement of the mean pulmonary artery pressure (mPAP) during right heart catheterisation (RHC) for the diagnosis. 4D flow MRI could provide non-invasive parameters to estimate the mPAP. Twenty-five patients with suspected CTEPH underwent cardiac MRI. Mean vortex duration (%), pulmonary distensibility, right ventricular volumes and function were measured using 4D flow MRI and cine sequences, and compared with the mPAP measured by RHC. The mPAP measured during RHC was 33 ± 16 mmHg (10–66 mmHg). PH (defined as mPAP > 20 mmHg) was present in 19 of 25 patients (76%). A vortical flow was observed in all but two patients (92%) on 4D flow images, and vortex duration showed good correlation with the mPAP (r = 0.805; p < 0.0001). Youden index analysis showed that a vortex duration of 8.6% of the cardiac cycle provided a 95% sensitivity and an 83% specificity to detect PH. Reliability for the measurement of vortex duration was excellent for both intra-observer ICC = 0.823 and inter-observer ICC = 0.788. Vortex duration could be a useful parameter to non-invasively estimate mPAP in patients with suspected CTEPH.

Keywords
  • 4D flow MRI
  • Cardiac MRI
  • Chronic thromboembolic disease
  • Pulmonary hypertension
  • Right heart catheterisation
  • Vortex duration
  • Vortical flow
Citation (ISO format)
DEUX, Jean-François et al. Correlation between Pulmonary Artery Pressure and Vortex Duration Determined by 4D Flow MRI in Main Pulmonary Artery in Patients with Suspicion of Chronic Thromboembolic Pulmonary Hypertension (CTEPH). In: Journal of clinical medicine, 2022, vol. 11, n° 17, p. 5237. doi: 10.3390/jcm11175237
Main files (1)
Article (Published version)
Identifiers
Additional URL for this publicationhttps://www.mdpi.com/2077-0383/11/17/5237
Journal ISSN2077-0383
82views
28downloads

Technical informations

Creation30/11/2022 12:40:30
First validation16/05/2023 07:09:49
Update time16/05/2023 07:29:43
Status update16/05/2023 07:29:43
Last indexation01/11/2024 05:01:58
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack