Scientific article

Quantification of myocardial perfusion with FAST sequence and Gd bolus in patients with normal cardiac function

Published inJournal of magnetic resonance imaging, vol. 9, no. 2, p. 197-203
Publication date1999-02

The present study reports on a new calibration of the magnetic resonance imaging (MRI) signal intensity of a fast gradient-echo sequence used for in vivo myocardial perfusion quantification in patients. The signal from a FAST sequence preceded by a arrhythmia-insensitive magnetization preparation was calibrated in vitro using tubes filled with various gadolinium (Gd) solutions. Single short-axis views of the heart were obtained in patients (n = 10) with normal cardiac function. Myocardial and blood signal intensity were converted to concentration of Gd according to the in vitro calibration curve and fitted by a one-compartment model. K1 [first-order transfer constant from the blood to the myocardium for the gadolinium-diethylene-triamine-pentaacetic acid (Gd-DTPA)] and Vd (distribution volume of Gd-DTPA in myocardium) obtained from the fit of the MRI-derived perfusion curves were 0.72 ± 0.22 (mL/min/g) and 15.3 ± 5.22%. These results were in agreement with previous observations on animals and demonstrated that a reliable measurement of myocardial perfusion can be obtained by MRI in patients with an in vitro calibration procedure.

  • Calibration
  • Contrast Media
  • Coronary Circulation / physiology
  • Female
  • Gadolinium DTPA
  • Heart / anatomy & histology
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Models, Cardiovascular
  • Phantoms, Imaging
Citation (ISO format)
VALLÉE, Jean-Paul et al. Quantification of myocardial perfusion with FAST sequence and Gd bolus in patients with normal cardiac function. In: Journal of magnetic resonance imaging, 1999, vol. 9, n° 2, p. 197–203. doi: 10.1002/(sici)1522-2586(199902)9:2<197::aid-jmri7>3.0.co;2-x
Main files (1)
Article (Published version)
ISSN of the journal1053-1807

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