en
Scientific article
English

Quantification of myocardial perfusion with FAST sequence and Gd bolus in patients with normal cardiac function

Published inJournal of magnetic resonance imaging, vol. 9, no. 2, p. 197-203
Publication date1999-02
Abstract

The present study reports on a new calibration of the magnetic resonance imaging (MRI) signal intensity of a fast gradient-echo sequence used for in vivo myocardial perfusion quantification in patients. The signal from a FAST sequence preceded by a arrhythmia-insensitive magnetization preparation was calibrated in vitro using tubes filled with various gadolinium (Gd) solutions. Single short-axis views of the heart were obtained in patients (n = 10) with normal cardiac function. Myocardial and blood signal intensity were converted to concentration of Gd according to the in vitro calibration curve and fitted by a one-compartment model. K1 [first-order transfer constant from the blood to the myocardium for the gadolinium-diethylene-triamine-pentaacetic acid (Gd-DTPA)] and Vd (distribution volume of Gd-DTPA in myocardium) obtained from the fit of the MRI-derived perfusion curves were 0.72 ± 0.22 (mL/min/g) and 15.3 ± 5.22%. These results were in agreement with previous observations on animals and demonstrated that a reliable measurement of myocardial perfusion can be obtained by MRI in patients with an in vitro calibration procedure.

eng
Keywords
  • Calibration
  • Contrast Media
  • Coronary Circulation / physiology
  • Female
  • Gadolinium DTPA
  • Heart / anatomy & histology
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Models, Cardiovascular
  • Phantoms, Imaging
Citation (ISO format)
VALLÉE, Jean-Paul et al. Quantification of myocardial perfusion with FAST sequence and Gd bolus in patients with normal cardiac function. In: Journal of magnetic resonance imaging, 1999, vol. 9, n° 2, p. 197–203. doi: 10.1002/(sici)1522-2586(199902)9:2<197::aid-jmri7>3.0.co;2-x
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Article (Published version)
accessLevelRestricted
ISSN of the journal1053-1807
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