Quantification of myocardial perfusion with FAST sequence and Gd bolus in patients with normal cardiac function

Article Article scientifique Article Quantification of myocardial perfusion with FAST sequence and Gd bolus in patients with normal cardiac function eng 1999-02 author Vallée Jean-Paul 0000-0001-7546-2013 Départment de Radiologie, Hôpital Universitaue de Geneve, Switzerland. jean-paul.vallee@hcuge.ch 29185 Département de radiologie et informatique médicale (RADIO) author Lazeyras François 512748 Département de radiologie et informatique médicale (RADIO) author Kasuboski Larry author Chatelain Pascal 28124 Département de médecine (DEMED) author Howarth Nigel author Righetti Alberto 25378 author Didier Dominique 27954 197-203 10.1002/(sici)1522-2586(199902)9:2<197::aid-jmri7>3.0.co;2-x 10077013 1053-1807 https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1522-2586(199902)9:2%3C197::AID-JMRI7%3E3.0.CO;2-X The present study reports on a new calibration of the magnetic resonance imaging (MRI) signal intensity of a fast gradient-echo sequence used for in vivo myocardial perfusion quantification in patients. The signal from a FAST sequence preceded by a arrhythmia-insensitive magnetization preparation was calibrated in vitro using tubes filled with various gadolinium (Gd) solutions. Single short-axis views of the heart were obtained in patients (n = 10) with normal cardiac function. Myocardial and blood signal intensity were converted to concentration of Gd according to the in vitro calibration curve and fitted by a one-compartment model. K1 [first-order transfer constant from the blood to the myocardium for the gadolinium-diethylene-triamine-pentaacetic acid (Gd-DTPA)] and Vd (distribution volume of Gd-DTPA in myocardium) obtained from the fit of the MRI-derived perfusion curves were 0.72 ± 0.22 (mL/min/g) and 15.3 ± 5.22%. These results were in agreement with previous observations on animals and demonstrated that a reliable measurement of myocardial perfusion can be obtained by MRI in patients with an in vitro calibration procedure. Calibration Contrast Media Coronary Circulation / physiology Female Gadolinium DTPA Heart / anatomy & histology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods Male Middle Aged Models, Cardiovascular Phantoms, Imaging Dewey 616.0757 Dewey 616 56 Département de médecine 221 62 Département de radiologie et informatique médicale 227 false 286 Imagerie cardiaque fonctionnelle 541 284 Groupe Lazeyras Francois (IRM fonctionnelle et métabolique) 539 Journal of magnetic resonance imaging 9 2 2058a70f-bf40-4d39-a957-e49b14f99a13 Article (Published version) Restricted QUANTIFICATION OF MYOCARDIAL PERFUS.pdf 193704 application/pdf 16ee10485e6a1fb79461291db6ade3dfc2daff87a3ee29356aadd4287e24cf4c restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale

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Quantification of myocardial perfusion with FAST sequence and Gd bolus in patients with normal cardiac function	Journal of magnetic resonance imaging			1999	59	0

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Chatelain, Pascal