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Title

Current role of liquid chromatography coupled to mass spectrometry in clinical toxicology screening methods
Authors
Viette, Véronique
Fathi, Marc
Rudaz, Serge
Hochstrasser, Denis
Veuthey, Jean-Luc
Published in Clinical Chemistry and Laboratory Medicine. 2011, vol. 49, no. 7, p. 1091-1103
Abstract Toxicological screening is the analysis of a biological specimen to detect and identify compounds in patients admitted to the hospital with acute intoxication of unknown origin. The screening of a wide range of toxicologically relevant compounds in biological samples is a serious challenge for clinical laboratories. The high selectivity and sensitivity of liquid chromatography coupled to mass spectrometry or tandem mass spectrometry technology provides an attractive alternative to the current methods. For these reasons, an increasing number of applications for multi-target screening or general screening of unknown compounds in biological matrices are being published. This paper is an overview of sample clean-up, chromatographic separation and mass spectrometry detection procedures which can be combined to obtain screening methods adapted to the constraints and needs of various laboratories, and none specifically in clinical toxicology. Currently the techniques are in the hands of specialists, principally in academic institutes. However, the evolution in technology should allow application of the techniques as a tool in toxicology laboratories and thus more widespread exploitation of their potential.
Keywords Clinical toxicology — Identification — Liquid chromatography/mass spectrometry (LC/MS) — Mass spectra — Screening.
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Article (Published version) (107 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté des sciences / Section des sciences pharmaceutiques
Research group La protéomique au service de la clinique (270)
Citation
(ISO format) 		VIETTE, Véronique et al. Current role of liquid chromatography coupled to mass spectrometry in clinical toxicology screening methods. In: Clinical Chemistry and Laboratory Medicine, 2011, vol. 49, n° 7, p. 1091-1103. doi: 10.1515/CCLM.2011.182 https://archive-ouverte.unige.ch/unige:16747

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Deposited on : 2011-08-05

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