Scientific article
Open access

A population-based serological study of post-COVID syndrome prevalence and risk factors in children and adolescents

Published inNature communications, vol. 13, no. 1, 7086
Publication date2022-11-29
First online date2022-11-29

Post-COVID syndrome remains poorly studied in children and adolescents. Here, we aimed to investigate the prevalence and risk factors of pediatric post-COVID in a population-based sample, stratifying by serological status. Children from the SEROCoV-KIDS cohort study (State of Geneva, Switzerland), aged 6 months to 17 years, were tested for anti-SARS-CoV-2 N antibodies (December 2021-February 2022) and parents filled in a questionnaire on persistent symptoms in their children (lasting over 12 weeks) compatible with post-COVID. Of 1034 children tested, 570 (55.1%) were seropositive. The sex- and age-adjusted prevalence of persistent symptoms among seropositive children was 9.1% (95%CI: 6.7;11.8) and 5.0% (95%CI: 3.0;7.1) among seronegatives, with an adjusted prevalence difference (ΔaPrev) of 4.1% (95%CI: 1.1;7.3). Stratifying per age group, only adolescents displayed a substantial risk of having post-COVID symptoms (ΔaPrev = 8.3%, 95%CI: 3.5;13.5). Identified risk factors for post-COVID syndrome were older age, having a lower socioeconomic status and suffering from chronic health conditions, especially asthma. Our findings show that a significant proportion of seropositive children, particularly adolescents, experienced persistent COVID symptoms. While there is a need for further investigations, growing evidence of pediatric post-COVID urges early screening and primary care management.

  • Adolescent
  • Antibodies, Viral
  • Child
  • Cohort Studies
  • Humans
  • Prevalence
  • Risk Factors
  • Syndrome
  • COVID-19 / epidemiology
  • Jacobs Foundation and Federal Office of public health -
Citation (ISO format)
DUMONT, Roxane et al. A population-based serological study of post-COVID syndrome prevalence and risk factors in children and adolescents. In: Nature communications, 2022, vol. 13, n° 1, p. 7086. doi: 10.1038/s41467-022-34616-8
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Article (Published version)
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ISSN of the journal2041-1723

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