This thesis introduces, compiles, and discusses innovative geospatial components developed for and applied to the project SNAKE-BYTE. Focusing on the Terai region of Nepal, we address snakebite disease from a One Health perspective aiming to improve the snakebite situation and prevent its escalation. For this, we developed a multi-cluster, cross-sectional, household random survey covering the Terai region of Nepal and interviewed 13'879 households. The overall objective of this research was to use the collected data and freely available geospatial information to assess the impact of their interactions on snakebite risk and vulnerability, and to propose solutions. We present a literature review, the SNAKE-BYTE project methods for cluster, household, and field data collection, a risk analysis using the INLA geostatistical approach, and a vulnerability analysis that combined risk results with a multi-layered analysis of accessibility to medical treatment. Finally, we propose optimisation measures to improve snakebite health coverage.