en
Scientific article
Open access
English

Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns

Published inMolecules, vol. 26, no. 13, 3839
Publication date2021-06-24
First online date2021-06-24
Abstract

Multidrug resistance infections are the main cause of failure in the pro-regenerative cell-mediated therapy of burn wounds. The collagen-based matrices for delivery of cells could be potential substrates to support bacterial growth and subsequent lysis of the collagen leading to a cell therapy loss. In this article, we report the development of a new generation of cell therapy formulations with the capacity to resist infections through the bactericidal effect of antimicrobial peptide dendrimers and the anti-virulence effect of anti-quorum sensing MvfR (PqsR) system compounds, which are incorporated into their formulation. Anti-quorum sensing compounds limit the pathogenicity and antibiotic tolerance of pathogenic bacteria involved in the burn wound infections, by inhibiting their virulence pathways. For the first time, we report a biological cell therapy dressing incorporating live progenitor cells, antimicrobial peptide dendrimers, and anti-MvfR compounds, which exhibit bactericidal and anti-virulence properties without compromising the viability of the progenitor cells.

eng
Keywords
  • MvfR
  • PqsR
  • Anti-infection dressing
  • Antimicrobial peptide dendrimers
  • Biological bandage
  • Burn wound
  • Cell therapy
  • Quorum-sensing inhibitors
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Burns / microbiology
  • Burns / pathology
  • Burns / therapy
  • Cell- and Tissue-Based Therapy
  • Cells, Cultured
  • Dendrimers / chemistry
  • Dendrimers / pharmacology
  • Humans
  • Pore Forming Cytotoxic Proteins / chemistry
  • Pore Forming Cytotoxic Proteins / pharmacology
  • Pseudomonas Infections / drug therapy
  • Pseudomonas Infections / metabolism
  • Pseudomonas Infections / mortality
  • Pseudomonas aeruginosa / growth & development
  • Quorum Sensing / drug effects
Citation (ISO format)
JAFARI, Paris et al. Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns. In: Molecules, 2021, vol. 26, n° 13, p. 3839. doi: 10.3390/molecules26133839
Main files (1)
Article (Published version)
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Identifiers
ISSN of the journal1420-3049
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Technical informations

Creation03/03/2022 10:00:00 AM
First validation03/03/2022 10:00:00 AM
Update time03/16/2023 7:41:36 AM
Status update03/16/2023 7:41:34 AM
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