Alpha-1 Antitrypsin Reduces Disease Progression in a Mouse Model of Charcot-Marie-Tooth Type 1A: A Role for Decreased Inflammation and ADAM-17 Inhibition
Contributeurs/tricesZhukovsky, Nikolay; Silvano, Marianna; Filloux, Thierry; Gonzalez, Sergio; Krause, Karl-Heinz
Publié dansInternational journal of molecular sciences, vol. 23, no. 13, 7405
Date de publication2022-07-03
Date de mise en ligne2022-07-03
Résumé
Mots-clés
- CMT1A
- MHC class II (MHCII)
- Hereditary motor and sensory neuropathy (HMSN)
- Interleukin-6 (IL-6)
- Peripheral myelin protein (PMP22)
- Recombinant AAT
- ADAM17 Protein / genetics
- Animals
- Charcot-Marie-Tooth Disease / drug therapy
- Charcot-Marie-Tooth Disease / genetics
- Charcot-Marie-Tooth Disease / metabolism
- Disease Models, Animal
- Disease Progression
- Inflammation / drug therapy
- Mice
- Mice, Transgenic
- Myelin Proteins / genetics
- Alpha 1-Antitrypsin Deficiency
Structure d'affiliation
Groupe de recherche
Citation (format ISO)
ZHUKOVSKY, Nikolay et al. Alpha-1 Antitrypsin Reduces Disease Progression in a Mouse Model of Charcot-Marie-Tooth Type 1A: A Role for Decreased Inflammation and ADAM-17 Inhibition. In: International journal of molecular sciences, 2022, vol. 23, n° 13, p. 7405. doi: 10.3390/ijms23137405
Fichiers principaux (1)
Article (Published version)
Fichiers secondaires (11)
Identifiants
- PID : unige:163546
- DOI : 10.3390/ijms23137405
- PMID : 35806409
- PMCID : PMC9266995
ISSN du journal1422-0067