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Article scientifique
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Pseudomonas aeruginosa rhamnolipid micelles deliver toxic metabolites and antibiotics into Staphylococcus aureus

Publié dansiScience, vol. 25, no. 1, 103669
Date de publication2022-01-21
Date de mise en ligne2021-12-20
Résumé

Efficient delivery of toxic compounds to bacterial competitors is essential during interspecies microbial warfare. Rhamnolipids (RLPs) are glycolipids produced by Pseudomonas and Burkholderia species involved in solubilization and uptake of environmental aliphatic hydrocarbons and perform as biosurfactants for swarming motility. Here, we show that RLPs produced by Pseudomonas aeruginosa associate to form micelles. Using high-resolution microscopy, we found that RLP micelles serve as carriers for self-produced toxic compounds, which they deliver to Staphylococcus aureus cells, thereby enhancing and accelerating S. aureus killing. RLPs also potentiated the activity of lincosamide antibiotics, suggesting that RLP micelles may transport not only self-produced but also heterologous compounds to target competing bacterial species.

eng
Mots-clés
  • Lipid
  • Microbiology
Citation (format ISO)
GDANIEC, Bartosz Gérard et al. <i>Pseudomonas aeruginosa</i> rhamnolipid micelles deliver toxic metabolites and antibiotics into <i>Staphylococcus aureus</i>. In: iScience, 2022, vol. 25, n° 1, p. 103669. doi: 10.1016/j.isci.2021.103669
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Article (Published version)
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Identifiants
ISSN du journal2589-0042
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Informations techniques

Création03/03/2022 08:14:00
Première validation03/03/2022 08:14:00
Heure de mise à jour16/03/2023 07:29:24
Changement de statut16/03/2023 07:29:23
Dernière indexation01/02/2024 08:43:33
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