The latest European guidelines for cardiovascular prevention were published in 2021. As compared to the previous 2016 edition, these guidelines include some new concepts. First, the estimation of cardiovascular risk in apparently healthy persons now encompasses for the first time both fatal and nonfatal events, including myocardial infarction and stroke, using the new SCORE2 and SCORE2-OP. Second, the cardiovascular risk thresholds estimated with the scores are now stratified by age. Medical comorbidities play a more important role in risk estimation and preventive treatment. Finally, in the interest of a more personalized management, a step-by-step attitude is proposed to reach therapeutic goals adapted to the patient.