Scientific article
Open access

Challenges in ESI-MS-based Untargeted Metabolomics

Published inChimia, vol. 76, no. 1-2, 90
Publication date2022-02-23
First online date2022-02-23

Untargeted metabolomics is now widely recognized as a useful tool for exploring metabolic changes taking place in biological systems under different conditions. In this article, we aim to provide a short overview of the liquid-phase separation methods hyphenated to MS to perform untargeted metabolomics of biological samples. Each approach is complemented by up-to-date literature to guide readers, as well as practical information for avoiding or fixing some of the most frequently encountered pitfalls. This article covers mainly data acquisition, but a short discussion is provided regarding signal processing and data treatment, as well as data analysis and its biological interpretation in the context of metabolomic studies.

Citation (ISO format)
TOBOLKINA, Elena et al. Challenges in ESI-MS-based Untargeted Metabolomics. In: Chimia, 2022, vol. 76, n° 1-2, p. 90. doi: 10.2533/chimia.2022.90
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ISSN of the journal0009-4293

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