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Scientific article
English

402.5: Human Amniotic Epithelial Cells Immunomodulatory Properties Protect Islets Against Inflammatory Cytokines In Vitro

Contributors

Lebreton, Fanny; Bellofatto, Kevin; Wassmer, Charles-Henri; Perez, Lisa Laura; Khatri, Rahul; Hasany, Masoud; Hanna, Reine; Oliveira Almeida Fonseca, Laura Do Mar; Cottet-Dumoulin, David; Parnaud, Géraldine; Bosco, Domenico; Berney, Thierry; Berishvili Berney, Ekaterine

Published in

Transplantation, vol. 105, no. 12S2, S29

Publication date

2021-12-01

Abstract

Inflammation is a primary contributor to early graft loss and poor islet engraftment. Human amniotic epithelial cells (hAEC) possess regenerative, immunomodulatory and anti-inflammatory properties. In particular, these cells express HLA-G and HLA-E, involved in immunomodulation and immune tolerance. Here, we hypothesized that hAECs could protect islets from cellular damage induced by proinflammatory cytokines and we assessed the cytokine-induced expression of HLA-G and HLA-E in hAECs.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

LEBRETON, Fanny et al. 402.5: Human Amniotic Epithelial Cells Immunomodulatory Properties Protect Islets Against Inflammatory Cytokines In Vitro. In: Transplantation, 2021, vol. 105, n° 12S2, p. S29. doi: 10.1097/01.tp.0000804448.91605.97

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0041-1337
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1downloads

Technical informations

Creation

22/12/2021 14:14:00

First validation

22/12/2021 14:14:00

Update

16/03/2023 06:29:37

Status update

16/03/2023 06:29:36

Last indexation

01/11/2024 01:37:08
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