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Scientific article
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c-Maf enforces cytokine production and promotes memory-like responses in mouse and human type 2 innate lymphoid cells

Published inEMBO journal, e109300
Publication date2022-04-25
First online date2022-04-25
Abstract

Group-2 innate lymphoid cells (ILC2s), which are involved in type 2 inflammatory diseases such as allergy, can exhibit immunological memory, but the basis of this ILC2 "trained immunity" has remained unclear. Here, we found that stimulation with IL-33/IL-25 or exposure to the allergen papain induces the expression of the transcription factor c-Maf in mouse ILC2s. Chronic papain exposure results in high production of IL-5 and IL-13 cytokines and lung eosinophil recruitment, effects that are blocked by c-Maf deletion in ILCs. Transcriptomic analysis revealed that knockdown of c-Maf in ILC2s suppresses expression of type 2 cytokine genes, as well as of genes linked to a memory-like phenotype. Consistently, c-Maf was found highly expressed in human adult ILC2s but absent in cord blood and required for cytokine production in isolated human ILC2s. Furthermore, c-Maf-deficient mouse or human ILC2s failed to exhibit strengthened ("trained") responses upon repeated challenge. Thus, the expression of c-Maf is indispensable for optimal type 2 cytokine production and proper memory-like responses in group-2 innate lymphoid cells.

eng
Keywords
  • ILC2
  • C-Maf
  • Immune training
  • Lung inflammation
Affiliation Not a UNIGE publication
Citation (ISO format)
TRABANELLI, Sara et al. c-Maf enforces cytokine production and promotes memory-like responses in mouse and human type 2 innate lymphoid cells. In: EMBO journal, 2022, p. e109300. doi: 10.15252/embj.2021109300
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ISSN of the journal0261-4189
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Technical informations

Creation05/03/2022 2:42:00 PM
First validation05/03/2022 2:42:00 PM
Update time03/16/2023 6:28:57 AM
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