en
Scientific article
English

The interaction of lithium with forskolin-inhibited meiotic maturation of denuded mouse oocytes

Published inExperimental cell research, vol. 179, no. 1, p. 298-302
Publication date1988-11
Abstract

Lithium reverses at millimolar concentrations and in a dose-dependent manner the inhibition of meiotic reinitiation (GVBD) induced by an activator of adenylate cyclase, forskolin, and does this independently of exogenous myo-inositol. These results argue for a pivotal role of adenylate cyclase in the regulation of meiotic resumption and for a possible action of lithium on G proteins rather than at the level of phosphatidylinositol resynthesis.

eng
Keywords
  • Animals
  • Bucladesine / pharmacology
  • Colforsin / pharmacology
  • Dose-Response Relationship, Drug
  • Lithium / pharmacology
  • Meiosis / drug effects
  • Mice
  • Oocytes / cytology
  • Oocytes / drug effects
Citation (ISO format)
GAVIN PERRIN, Anne-Claude, SCHORDERET, Sabine. The interaction of lithium with forskolin-inhibited meiotic maturation of denuded mouse oocytes. In: Experimental cell research, 1988, vol. 179, n° 1, p. 298–302. doi: 10.1016/0014-4827(88)90369-2
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0014-4827
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