Hg methylation in the oxic water column of marine environments has been linked to the presence of suspended and settling particles known as marine snow, which acts as a micro-niche for MeHg production. While marine snow has been thoroughly studied, its freshwater counterpart, lake snow, received less attention, even though few works have highlighted its ability to be a micro environment for Hg methylation in freshwater systems. Here we present new data of MeHg and THg concentrations in the lake snow of a deep peri-alpine lake (Lake Geneva, Switzerland-France). Particles were sampled from the lake and from its main tributaries using continuous flow filtration and continuous flow centrifugation, respectively. MeHg concentrations ranged from 0.48 ± 0.09 ng/g to 9.61 ± 0.67 ng/g in the lake particles, and from 0.30 ± 0.08 ng/g to 2.41 ± 0.14 ng/g in tributary particles. Our results suggest that lake snow is a likely micro-niche for Hg methylation, like marine snow, and that this methylation takes place inside the particles with a subsequent diffusion to the water column. Moreover, we propose a conceptual model to explain the MeHg behavior related to the lake snow along Lake Geneva water column and a mass balance model to estimate the time required to reach the steady state of MeHg in the water column. Our calculation indicates that the steady-state is reached after 37 days. This result is compatible with particles residence times from the literature on Lake Geneva. These particles forming the lake snow are probably a major entry point into the lake’s food chain.