Scientific article
Open access

UniProt: the universal protein knowledgebase in 2021

ContributorsUniProt Consortium
CollaboratorsTeodoro, Douglasorcid
Published inNucleic acids research, vol. 49, no. D1, p. D480-D489
Publication date2021-01-08

The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this article, we describe significant updates that we have made over the last two years to the resource. The number of sequences in UniProtKB has risen to approximately 190 million, despite continued work to reduce sequence redundancy at the proteome level. We have adopted new methods of assessing proteome completeness and quality. We continue to extract detailed annotations from the literature to add to reviewed entries and supplement these in unreviewed entries with annotations provided by automated systems such as the newly implemented Association-Rule-Based Annotator (ARBA). We have developed a credit-based publication submission interface to allow the community to contribute publications and annotations to UniProt entries. We describe how UniProtKB responded to the COVID-19 pandemic through expert curation of relevant entries that were rapidly made available to the research community through a dedicated portal. UniProt resources are available under a CC-BY (4.0) license via the web at https://www.uniprot.org/.

  • COVID-19 / epidemiology
  • COVID-19 / prevention & control
  • COVID-19 / virology
  • Computational Biology / methods
  • Data Curation / methods
  • Databases, Protein
  • Humans
  • Internet
  • Knowledge Bases
  • Molecular Sequence Annotation / methods
  • Pandemics
  • Proteome / genetics
  • Proteome / metabolism
  • Proteomics / methods
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / metabolism
  • SARS-CoV-2 / physiology
  • User-Computer Interface
  • Viral Proteins / genetics
  • Viral Proteins / metabolism
Affiliation Not a UNIGE publication
Citation (ISO format)
UniProt Consortium. UniProt: the universal protein knowledgebase in 2021. In: Nucleic acids research, 2021, vol. 49, n° D1, p. D480–D489. doi: 10.1093/nar/gkaa1100
Main files (1)
Article (Published version)
ISSN of the journal0305-1048

Technical informations

Creation02/03/2022 10:23:00 AM
First validation02/03/2022 10:23:00 AM
Update time03/16/2023 2:53:20 AM
Status update03/16/2023 2:53:19 AM
Last indexation02/12/2024 12:21:04 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack