Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1

Pihán, Philippe; Lisbona, Fernanda; Borgonovo, Janina; Edwards-Jorquera, Sandra; Nunes-Hasler, Paula; Castillo, Karen; Kepp, Oliver; Urra, Hery; Saarnio, Suvi; Vihinen, Helena; Carreras Sureda, Amado; Forveille, Sabrina; Sauvat, Allan; De Giorgis, Daniela; Pupo, Amaury; Rodríguez, Diego A.; Quarato, Giovanni; Sagredo, Alfredo; Lourido, Fernanda; Letai, Anthony; Latorre, Ramon; Kroemer, Guido; Demaurex, Nicolas; Jokitalo, Eija; Concha, Miguel L.; Glavic, Álvaro; Green, Douglas R.; Hetz, Claudio

doi:10.1126/sciadv.abe5469

Scientific article

English

Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1

Published inScience advances, vol. 7, no. 46, eabe5469

Publication date2021-11-12

Abstract

RECS1, a member of the TMBIM family, triggers lysosomal membrane permeabilization in cells undergoing lysosomal stress.

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Research groups

Funding

Citation (ISO format)

PIHÁN, Philippe et al. Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1. In: Science advances, 2021, vol. 7, n° 46, p. eabe5469. doi: 10.1126/sciadv.abe5469

Article (Published version)

CC BY-NC

Identifiers

PID : unige:159185
DOI : 10.1126/sciadv.abe5469
PMID : 34767445
PMCID : PMC8589314

Commercial URLhttps://www.science.org/doi/10.1126/sciadv.abe5469

ISSN of the journal2375-2548

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Creation02/21/2022 3:30:00 PM

First validation02/21/2022 3:30:00 PM

Update time03/16/2023 2:44:39 AM

Status update03/16/2023 2:44:37 AM

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Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1

RECS1, a member of the TMBIM family, triggers lysosomal membrane permeabilization in cells undergoing lysosomal stress.

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