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Scientific article
Open access
English

Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα

Published inNature communications, vol. 12, no. 1, 7031
Publication date2021-12-02
First online date2021-12-02
Abstract

Intestinal surface changes in size and function, but what propels these alterations and what are their metabolic consequences is unknown. Here we report that the food amount is a positive determinant of the gut surface area contributing to an increased absorptive function, reversible by reducing daily food. While several upregulated intestinal energetic pathways are dispensable, the intestinal PPARα is instead necessary for the genetic and environment overeating–induced increase of the gut absorptive capacity. In presence of dietary lipids, intestinal PPARα knock-out or its pharmacological antagonism suppress intestinal crypt expansion and shorten villi in mice and in human intestinal biopsies, diminishing the postprandial triglyceride transport and nutrient uptake. Intestinal PPARα ablation limits systemic lipid absorption and restricts lipid droplet expansion and PLIN2 levels, critical for droplet formation. This improves the lipid metabolism, and reduces body adiposity and liver steatosis, suggesting an alternative target for treating obesity.

eng
Funding
  • Clayton foundation for biomedical research -
  • European Commission - Microbiota-host interactions for integrative metabolic health reprogramming [815962]
Citation (ISO format)
STOJANOVIC, Ozren et al. Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα. In: Nature communications, 2021, vol. 12, n° 1, p. 7031. doi: 10.1038/s41467-021-27133-7
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Article (Published version)
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Identifiers
ISSN of the journal2041-1723
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