The antidepressant Sertraline inhibits CatSper Ca<sup>2+</sup> channels in human sperm

RAHBAN, Rita et al. The antidepressant Sertraline inhibits CatSper Ca<sup>2+</sup> channels in human sperm. In: Human reproduction, 2021, vol. 36, n° 10, p. 2638–2648. doi: 10.1093/humrep/deab190

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PID : unige:158953
DOI : 10.1093/humrep/deab190
PMID : 34486673
PMCID : PMC8450872

Commercial URLhttps://academic.oup.com/humrep/article/36/10/2638/6364849

ISSN of the journal0268-1161

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Creation10/04/2021 1:02:00 PM

First validation10/04/2021 1:02:00 PM

Update time03/16/2023 2:40:54 AM

Status update03/16/2023 2:40:51 AM

Last indexation05/06/2024 9:57:23 AM

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The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm

Study question: Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm? Summary answer: The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca2+ channel CatSper and affects human sperm function in vitro.

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The antidepressant Sertraline inhibits CatSper Ca²⁺ channels in human sperm

Study question: Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm?

Summary answer: The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca²⁺ channel CatSper and affects human sperm function in vitro.