The antidepressant Sertraline inhibits CatSper Ca<sup>2+</sup> channels in human sperm

RAHBAN, Rita et al. The antidepressant Sertraline inhibits CatSper Ca²⁺ channels in human sperm. In: Human reproduction, 2021, vol. 36, n° 10, p. 2638–2648. doi: 10.1093/humrep/deab190

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PID : unige:158953
DOI : 10.1093/humrep/deab190
PMID : 34486673
PMCID : PMC8450872

Additional URL for this publicationhttps://academic.oup.com/humrep/article/36/10/2638/6364849

Journal ISSN0268-1161

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Creation04/10/2021 13:02:00

First validation04/10/2021 13:02:00

Update16/03/2023 02:40:54

Status update16/03/2023 02:40:51

Last indexation01/11/2024 00:53:32

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The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm

Study question: Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm? Summary answer: The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca2+ channel CatSper and affects human sperm function in vitro.

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The antidepressant Sertraline inhibits CatSper Ca²⁺ channels in human sperm

Study question: Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm?

Summary answer: The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca²⁺ channel CatSper and affects human sperm function in vitro.