Scientific article
Open access

The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm

Published inHuman reproduction, vol. 36, no. 10, p. 2638-2648
Publication date2021-10
First online date2021-09-06

Study question: Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm?

Summary answer: The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca2+ channel CatSper and affects human sperm function in vitro.

  • Human sperm
  • Antidepressants
  • SSRI
  • Calcium signaling
  • CatSper
  • Acrosomal exocytosis
  • Sperm motility
  • Swiss Centre for Applied Human Toxicology (SCAHT) -
  • Département de l'Instruction Publique of the State of Geneva -
  • German Research Foundation - [CRU326]
  • Interdisciplinary Center for Clinical Research, Münster - [IZKF; Str/014/21]
  • Inovation Fund Denmark - [14-2013-4]
  • Kirsten and Freddy Johansen's Foundation - EDMaRC
Citation (ISO format)
RAHBAN, Rita et al. The antidepressant Sertraline inhibits CatSper Ca<sup>2+</sup> channels in human sperm. In: Human reproduction, 2021, vol. 36, n° 10, p. 2638–2648. doi: 10.1093/humrep/deab190
Main files (1)
Article (Published version)
Secondary files (5)
ISSN of the journal0268-1161

Technical informations

Creation10/04/2021 1:02:00 PM
First validation10/04/2021 1:02:00 PM
Update time03/16/2023 2:40:54 AM
Status update03/16/2023 2:40:51 AM
Last indexation08/31/2023 7:44:29 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack