PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

Sluysmans, Sophie; Mean, Isabelle; Xiao, Tong; Boukhatemi, Amina; Ferreira, Flavio; Jond, Lionel; Mutero-Maeda, Annick; Chang, Christopher J.; Citi, Sandra

doi:10.1091/mbc.E21-07-0355

Scientific article

Open access

English

PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

ContributorsSluysmans, Sophie; Mean, Isabelle; Xiao, Tong; Boukhatemi, Amina; Ferreira, Flavio; Jond, Lionel; Mutero-Maeda, Annick; Chang, Christopher J.; Citi, Sandra

Published inMolecular biology of the cell, vol. 32, no. 21

Publication date2021-11-01

Abstract

The WW-PLEKHA proteins PLEKHA5, PLEKHA6, and PLEKHA7 coordinate together with PDZD11 the anterograde traffic of the copper pump ATP7A from the trans-Golgi network to the cell periphery. WW-PLEKHAs promote PDZD11 interaction with the C-terminus of ATP7A and are required for maintaining low intracellular copper levels when cells face elevated copper.

Affiliation

Faculté des sciences / Section de biologie / Département de biologie cellulaire

Citation (ISO format)

SLUYSMANS, Sophie et al. PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis. In: Molecular biology of the cell, 2021, vol. 32, n° 21. doi: 10.1091/mbc.E21-07-0355

Article (Accepted version)

Article (Published version)

Identifiers

PID : unige:158431
DOI : 10.1091/mbc.E21-07-0355
PMID : 34613798

Commercial URLhttps://www.molbiolcell.org/doi/10.1091/mbc.E21-07-0355

ISSN of the journal1059-1524

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Creation01/26/2022 10:25:00 AM

First validation01/26/2022 10:25:00 AM

Update time03/16/2023 2:30:27 AM

Status update03/16/2023 2:30:26 AM

Last indexation01/17/2024 4:03:08 PM

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PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

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