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PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

Published inMolecular biology of the cell, vol. 32, no. 21
Publication date2021-11-01
Abstract

The WW-PLEKHA proteins PLEKHA5, PLEKHA6, and PLEKHA7 coordinate together with PDZD11 the anterograde traffic of the copper pump ATP7A from the trans-Golgi network to the cell periphery. WW-PLEKHAs promote PDZD11 interaction with the C-terminus of ATP7A and are required for maintaining low intracellular copper levels when cells face elevated copper.

Citation (ISO format)
SLUYSMANS, Sophie et al. PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis. In: Molecular biology of the cell, 2021, vol. 32, n° 21. doi: 10.1091/mbc.E21-07-0355
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ISSN of the journal1059-1524
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Technical informations

Creation01/26/2022 10:25:00 AM
First validation01/26/2022 10:25:00 AM
Update time03/16/2023 2:30:27 AM
Status update03/16/2023 2:30:26 AM
Last indexation05/06/2024 8:57:35 AM
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