PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

Article Article scientifique Article PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis eng 2021-11-01 author Sluysmans Sophie 846301 author Mean Isabelle 682897 author Xiao Tong author Boukhatemi Amina 836014 author Ferreira Flavio 840883 author Jond Lionel 96467 author Mutero-Maeda Annick 134426 author Chang Christopher J. author Citi Sandra 0000-0002-6537-4818 116085 10.1091/mbc.E21-07-0355 34613798 1059-1524 https://www.molbiolcell.org/doi/10.1091/mbc.E21-07-0355 <p>The WW-PLEKHA proteins PLEKHA5, PLEKHA6, and PLEKHA7 coordinate together with PDZD11 the anterograde traffic of the copper pump ATP7A from the trans-Golgi network to the cell periphery. WW-PLEKHAs promote PDZD11 interaction with the C-terminus of ATP7A and are required for maintaining low intracellular copper levels when cells face elevated copper.</p> Dewey 570 46 Département de biologie cellulaire 165 false 1441 Groupe Citi Molecular biology of the cell 32 21 df6e90a6-8894-4a2a-b778-459b38f51f29 Article (Accepted version) Public SluysmansetalREV2.pdf 554087 application/pdf 4f96cb19-d00d-48ff-b747-d746bd898b4f Article (Published version) Restricted SluysmansetalMBoC2021a.pdf 4064634 application/pdf openAccess Faculté des sciences / Section de biologie / Département de biologie cellulaire

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PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis	Molecular biology of the cell			2021	271	339

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