en
Scientific article
Open access
English

Chlorin endogenous to the north pacific brittle star ophiura sarsii for photodynamic therapy applications in breast cancer and glioblastoma models

Published inBiomedicines, vol. 10, no. 1, 134
Publication date2022-01-08
First online date2022-01-08
Abstract

Photodynamic therapy (PDT) represents a powerful avenue for anticancer treatment. PDT relies on the use of photosensitizers—compounds accumulating in the tumor and converted from benign to cytotoxic upon targeted photoactivation. We here describe (3S,4S)-14-Ethyl-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid (ETPA) as a major metabolite of the North Pacific brittle stars Ophiura sarsii. As a chlorin, ETPA efficiently produces singlet oxygen upon red-light photoactivation and exerts powerful sub-micromolar phototoxicity against a panel of cancer cell lines in vitro. In a mouse model of glioblastoma, intravenous ETPA injection combined with targeted red laser irradiation induced strong necrotic ablation of the brain tumor. Along with the straightforward ETPA purification protocol and abundance of O. sarsii, these studies pave the way for the development of ETPA as a novel natural product-based photodynamic therapeutic.

eng
Citation (ISO format)
KLIMENKO, Antonina et al. Chlorin endogenous to the north pacific brittle star ophiura sarsii for photodynamic therapy applications in breast cancer and glioblastoma models. In: Biomedicines, 2022, vol. 10, n° 1, p. 134. doi: 10.3390/biomedicines10010134
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal2227-9059
413views
96downloads

Technical informations

Creation01/24/2022 9:01:00 AM
First validation01/24/2022 9:01:00 AM
Update time03/16/2023 2:27:38 AM
Status update03/16/2023 2:27:37 AM
Last indexation05/06/2024 8:55:33 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack