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Chlorin endogenous to the north pacific brittle star ophiura sarsii for photodynamic therapy applications in breast cancer and glioblastoma models

Publié dansBiomedicines, vol. 10, no. 1, 134
Date de publication2022-01-08
Date de mise en ligne2022-01-08
Résumé

Photodynamic therapy (PDT) represents a powerful avenue for anticancer treatment. PDT relies on the use of photosensitizers—compounds accumulating in the tumor and converted from benign to cytotoxic upon targeted photoactivation. We here describe (3S,4S)-14-Ethyl-9-(hydroxymethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid (ETPA) as a major metabolite of the North Pacific brittle stars Ophiura sarsii. As a chlorin, ETPA efficiently produces singlet oxygen upon red-light photoactivation and exerts powerful sub-micromolar phototoxicity against a panel of cancer cell lines in vitro. In a mouse model of glioblastoma, intravenous ETPA injection combined with targeted red laser irradiation induced strong necrotic ablation of the brain tumor. Along with the straightforward ETPA purification protocol and abundance of O. sarsii, these studies pave the way for the development of ETPA as a novel natural product-based photodynamic therapeutic.

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Citation (format ISO)
KLIMENKO, Antonina et al. Chlorin endogenous to the north pacific brittle star ophiura sarsii for photodynamic therapy applications in breast cancer and glioblastoma models. In: Biomedicines, 2022, vol. 10, n° 1, p. 134. doi: 10.3390/biomedicines10010134
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Article (Published version)
Identifiants
ISSN du journal2227-9059
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Informations techniques

Création24.01.2022 09:01:00
Première validation24.01.2022 09:01:00
Heure de mise à jour16.03.2023 02:27:38
Changement de statut16.03.2023 02:27:37
Dernière indexation01.02.2024 07:17:52
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