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Scientific Article
unige:15799 
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Intact protein analysis in the biopharmaceutical field |
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| Published in | Journal of pharmaceutical and biomedical analysis. 2011, vol. 55, no. 4, p. 810-22 | |
| Abstract | In recent years, a growing number of biopharmaceutical proteins have been produced and are already available, or will be soon available, in the market. These molecules are more complex to analyze than conventional low molecular weight drugs, and thus need powerful analytical approaches for the entire development and delivery process. This review summarizes the analytical techniques available for intact protein determination and the main development steps in which they are applicable. A strong emphasis has been put on separation techniques, liquid chromatography and electrophoretic techniques, but mass spectrometry and spectroscopic approaches are also mentioned. Overall, we highlight how several analytical strategies are necessary to obtain global information. | |
| Keywords | Intact protein — Biopharmaceutical analysis — Analytical methods — Liquid chromatography — Capillary electrophoresis | |
| Identifiers | PMID: 21334842 | |
| Full text |
Article (Accepted version) (806 Kb) - Limited access to UNIGE Other version: http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6TGX-5223Y1K-6-1&_cdi=5266&_user=9565874&_pii=S0731708511000... |
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| Citation (ISO format) | STAUB SPORRI, Aline et al. Intact protein analysis in the biopharmaceutical field. In: Journal of pharmaceutical and biomedical analysis, 2011, vol. 55, n° 4, p. 810-22. doi: 10.1016/j.jpba.2011.01.031 https://archive-ouverte.unige.ch/unige:15799 |
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