Long COVID neuropsychological deficits after severe, moderate or mild infection
Background: There is growing awareness that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can include long-term neuropsychological deficits, even in its mild or moderate respiratory forms.
Methods: Standardized neuropsychological, psychiatric, neurological and olfactory tests were administered to 45 patients (categorized according to the severity of their respiratory symptoms during the acute phase) 236.51 ± 22.54 days post-discharge following SARS-CoV-2 infection.
Results: Deficits were found in all the domains of cognition and the prevalence of psychiatric symptoms was also high in the three groups. The severe performed more poorly on long-term episodic memory and exhibited greater anosognosia. The moderate had poorer emotion recognition, which was positively correlated with persistent olfactory dysfunction. The mild were more stressed, anxious and depressed.
Conclusion: The data support the hypothesis that the virus targets the central nervous system (and notably the limbic system), and support the notion of different neuropsychological phenotypes.
|Note||Déposé dans: medRxiv|
Preprint (1.4 MB) - Free access
|VORUZ, Philippe et al. Long COVID neuropsychological deficits after severe, moderate or mild infection. 2021. doi: 10.1101/2021.02.24.21252329 https://archive-ouverte.unige.ch/unige:157889|