⁸⁷Sr/⁸⁶Sr ratios increase gradually from early sedimentary to late diagenetic carbonate generations in the Pucará basin, central Peru. In parallel, 0 and C isotopes become lighter with the paragenetic sequence. The combined Sr-0-C isotopic data reveal that (1) early replacement dolomite precipitated from brines dominated by Upper Triassic and Lower Jurassic seawater; (2) late-stage sparry dolomite and coarse-crystalline calcite were deposited by ⁸⁷Sr-enriched, and ¹³C- and ¹⁸0- depleted brines most probably derived from detrital rocks at the base of the basin ; and (3) MVT deposits were formed by warm radiogenic brines, of similar origin, migrating over a considerable vertical distance from deep to shallow levels in the Pucara Group during the late diagenetic evolution of the basin.