Experimental cerebral palsy causes microstructural brain damage in areas associated to motor deficits but no spatial memory impairments in the developing rat

Sanchez, Oliver Lope; Carvalho, A S; Van De Looij, Yohan; Toulotte, A; Wyse, A T; Netto, C A; Sizonenko, Stéphane

doi:10.1016/j.brainres.2021.147389

Scientific article

English

Experimental cerebral palsy causes microstructural brain damage in areas associated to motor deficits but no spatial memory impairments in the developing rat

ContributorsSanchez, Oliver Lope; Carvalho, A S; Van De Looij, Yohan; Toulotte, A; Wyse, A T; Netto, C A; Sizonenko, Stéphane

Published inBrain Research, vol. 1761, 147389

Publication date2021

Abstract

Cerebral palsy (CP) is the major cause of motor and cognitive impairments during childhood. CP can result from direct or indirect structural injury to the developing brain. In this study, we aimed to describe brain damage and behavioural alterations during early adult life in a CP model using the combination of maternal inflammation, perinatal anoxia and postnatal sensorimotor restriction.

Keywords

Cerebral palsy
Inflammation
Anoxia
Sensorimotor restriction
Brain damage
Diffusion Tensor Imaging

Affiliation

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research group

L'imagerie cérébrale (184)

Citation (ISO format)

SANCHEZ, Oliver Lope et al. Experimental cerebral palsy causes microstructural brain damage in areas associated to motor deficits but no spatial memory impairments in the developing rat. In: Brain Research, 2021, vol. 1761, p. 147389. doi: 10.1016/j.brainres.2021.147389

Article (Published version)

Identifiers

PID : unige:157744
DOI : 10.1016/j.brainres.2021.147389
PMID : 33639200

Commercial URLhttps://www.sciencedirect.com/science/article/pii/S0006899321001141

ISSN of the journal0006-8993

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Experimental cerebral palsy causes microstructural brain damage in areas associated to motor deficits but no spatial memory impairments in the developing rat

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