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Title

Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies

Authors
Carmeli, Cristian
Kutalik, Zoltán
Mishra, Pashupati P.
Porcu, Eleonora
Delpierre, Cyrille
Delaneau, Olivier
Kelly-Irving, Michelle
Bochud, Murielle
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Published in Scientific reports. 2021, vol. 11, no. 1, 3100
Abstract Individuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the functioning of the immune system in adulthood. To address this, we explore the relationship across social-to-biological layers of early life social exposures on levels of adulthood inflammation and the mediating role of gene regulatory mechanisms, epigenetic and transcriptomic profiling from blood, in 2,329 individuals from two European cohort studies. Consistently across both studies, we find transcriptional activity explains a substantive proportion (78% and 26%) of the estimated effect of early life disadvantaged social exposures on levels of adulthood inflammation. Furthermore, we show that mechanisms other than cis DNA methylation may regulate those transcriptional fingerprints. These results further our understanding of social-to-biological transitions by pinpointing the role of gene regulation that cannot fully be explained by differential cis DNA methylation.
Identifiers
PMID: 33542415
PMCID: PMC7862626
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Other version: http://www.nature.com/articles/s41598-021-82714-2
Structures
Research groups Chimie et protéomique clinique (270)
Traits génétiques complexes (901)
Projects
European Commission: LIFEPATH
Swiss National Science Foundation: 33CM30-124087
European Commission: MULTIEPIGEN
UK Research and Innovation: MR/R024227/1
Swiss National Science Foundation: PZ00P3_147998
European Commission: TAXINOMISIS
Swiss National Science Foundation: 31003A_169929
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(ISO format)
CARMELI, Cristian et al. Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies. In: Scientific reports, 2021, vol. 11, n° 1, p. 3100. doi: 10.1038/s41598-021-82714-2 https://archive-ouverte.unige.ch/unige:157643

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Deposited on : 2021-12-23

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