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Doctoral thesis
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English

Evolution of Hoxd gene regulation

Number of pages119
Imprimatur date2021-09-07
Defense date2021-09-07
Abstract

The phenotypic diversity found in vertebrates is closely related to modifications in the transcription patterns of developmental genes. Developmental genes often participate in several patterning processes and are thus very well conserved. In contrast, their associated cis-regulatory elements (CREs) function in a mostly time and tissue specific manner. Genetic modifications within CREs may thus alter the pattern of expression of their target developmental gene in a spatiotemporal limited manner. Consequently, they may lead to morphological changes with less probability of associated lethality than mutations affecting coding sequences. For this reason, understanding the mechanisms of CREs evolution is key to gain insight into vertebrate diversification.

engfre
Keywords
  • Chromatin topology
  • TAD
  • Enhancers
  • Evolution
  • Gene regulation
  • Development
  • Teguments
  • Placodes
Research group
Citation (ISO format)
HINTERMANN, Aurélie. Evolution of Hoxd gene regulation. 2021. doi: 10.13097/archive-ouverte/unige:156593
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Creation11/03/2021 10:37:00 AM
First validation11/03/2021 10:37:00 AM
Update time03/06/2024 7:54:30 AM
Status update03/06/2024 7:54:30 AM
Last indexation03/06/2024 7:54:32 AM
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