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Scientific article
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English

Phylogeographical Analysis Reveals the Historic Origin, Emergence, and Evolutionary Dynamics of Methicillin-Resistant Staphylococcus aureus ST228

Published inFrontiers in Microbiology, vol. 11, 2063
Publication date2020
Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a common healthcare-associated pathogen that remains a major public health concern. Sequence type 228 (ST228) was first described in Germany and spread to become a successful MRSA clone in several European countries. In 2000, ST228 emerged in Lausanne and has subsequently caused several large outbreaks. Here, we describe the evolutionary history of this clone and identify the genetic changes underlying its expansion in Switzerland.

Keywords
  • MRSA
  • ST228
  • WGS
  • Epidemiology
  • Genomic epidemiology
  • Phylogeny
  • Phylogeography
Citation (ISO format)
ABDELBARY, Mohamed M H et al. Phylogeographical Analysis Reveals the Historic Origin, Emergence, and Evolutionary Dynamics of Methicillin-Resistant Staphylococcus aureus ST228. In: Frontiers in Microbiology, 2020, vol. 11, p. 2063. doi: 10.3389/fmicb.2020.02063
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ISSN of the journal1664-302X
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