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Scientific article
Open access
English

Life-course socioeconomic status and DNA methylation of genes regulating inflammation

Published inInternational Journal of Epidemiology, vol. 44, no. 4, p. 1320-1330
Publication date2015
Abstract

In humans, low socioeconomic status (SES) across the life course is associated with greater diurnal cortisol production, increased inflammatory activity and higher circulating antibodies for several pathogens, all suggesting a dampened immune response. Recent evidence suggests that DNA methylation of pro-inflammatory genes may be implicated in the biological embedding of the social environment.

Keywords
  • DNA Methylation
  • Female
  • Genome-Wide Association Study
  • Healthy Volunteers
  • Humans
  • Inflammation/genetics
  • Italy
  • Male
  • Middle Aged
  • Multivariate Analysis
  • NFATC Transcription Factors/genetics
  • Prospective Studies
  • Social Class
  • Social Environment
Affiliation Not a UNIGE publication
Citation (ISO format)
STRINGHINI, Silvia et al. Life-course socioeconomic status and DNA methylation of genes regulating inflammation. In: International Journal of Epidemiology, 2015, vol. 44, n° 4, p. 1320–1330. doi: 10.1093/ije/dyv060
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Article (Published version)
Identifiers
ISSN of the journal0300-5771
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