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Doctoral thesis
Open access
English

A novel dual-imaging probe for the detection of progressive ovarian cancer

Imprimatur date2021-09-29
Defense date2021-09-28
Abstract

Ovarian cancer is the seventh most common cancer in women worldwide, accounting for more deaths than any other cancer of the female reproductive system. In most of the cases, ovarian cancer will be diagnosed at the advanced stages, when cancer is already widely metastasized, often creating undetectable microscopic tumor spots that represent a major risk for disease progression, as a complete resection is rarely possible with the existing techniques. This thesis aimed at proposing a novel and innovative solution not only for diagnosis, but also for treatment planning, surgery guidance and post-resection validation for patients with ovarian cancer. The main goal was to develop a hybrid imaging tool specific for ovarian cancer with folate as targeting moiety, a chelator coordinating Ga-68 for PET imaging and fluorescent dye for surgery guidance. The probe was succesfully synthetized and demonstrated good performance on ovarian cancer cell model in vitro and in ovo.

eng
Keywords
  • Nuclear medicine
  • Fluorescent imaging
  • Hybrid imaging
  • Multimodal imaging
  • Hybrid probes
Research group
Citation (ISO format)
LITVINENKO, Alexandra. A novel dual-imaging probe for the detection of progressive ovarian cancer. 2021. doi: 10.13097/archive-ouverte/unige:156100
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Thesis
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Technical informations

Creation10/15/2021 10:37:00 AM
First validation10/15/2021 10:37:00 AM
Update time03/16/2023 1:43:47 AM
Status update03/16/2023 1:43:47 AM
Last indexation01/29/2024 10:54:23 PM
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