Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients

Bellon, Mathilde Anne; Schweblin, Cécilia; Lambeng, Nathalie Dominique; Cherpillod, Pascal; Vazquez Antelo, Jessica; Lalive d'Epinay, Patrice; Schibler, Manuel; Delbouille-Naulot Deffert, Christine

doi:10.1093/cid/ciaa1165

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Title		Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients
Authors		Bellon, Mathilde Anne Schweblin, Cécilia Lambeng, Nathalie Dominique Cherpillod, Pascal Vazquez Antelo, Jessica Lalive d'Epinay, Patrice Schibler, Manuel Delbouille-Naulot Deffert, Christine
Published in		Clinical infectious diseases. 2021, vol. 73, no. 9, p. e3102-e3105
Abstract		This study analyzed the cerebrospinal fluid features of 31 coronavirus disease 2019 (COVID-19) patients with neurological complications. We observed neither severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the cerebrospinal fluid, nor intrathecal immunoglobulin G (IgG) synthesis but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis.
Keywords		COVID-19 — SARS-CoV-2 — Blood-brain barrier — Intrathecal synthesis — Neurological manifestations
Identifiers		DOI: 10.1093/cid/ciaa1165 PMID: 32770235 PMCID: PMC7454353
Full text		Article (Published version) (152 Kb) - Free access Supplemental data (22 Kb) - Free access Other version: https://academic.oup.com/cid/article/73/9/e3102/5890019
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques
Research groups		Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843) Groupe Laurent Kaiser (virologie clinique) (668) Emerging viruses (993)
Citation (ISO format)		BELLON, Mathilde Anne et al. Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients. In: Clinical infectious diseases, 2021, vol. 73, n° 9, p. e3102-e3105. doi: 10.1093/cid/ciaa1165 https://archive-ouverte.unige.ch/unige:155981

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Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients