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Title

Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients

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Published in Clinical infectious diseases. 2021, vol. 73, no. 9, p. e3102-e3105
Abstract This study analyzed the cerebrospinal fluid features of 31 coronavirus disease 2019 (COVID-19) patients with neurological complications. We observed neither severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the cerebrospinal fluid, nor intrathecal immunoglobulin G (IgG) synthesis but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis.
Keywords COVID-19SARS-CoV-2Blood-brain barrierIntrathecal synthesisNeurological manifestations
Identifiers
PMID: 32770235
PMCID: PMC7454353
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Research groups Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)
Groupe Laurent Kaiser (virologie clinique) (668)
Emerging viruses (993)
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BELLON, Mathilde Anne et al. Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients. In: Clinical infectious diseases, 2021, vol. 73, n° 9, p. e3102-e3105. doi: 10.1093/cid/ciaa1165 https://archive-ouverte.unige.ch/unige:155981

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Deposited on : 2021-11-03

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