Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients

Bellon, Mathilde Anne; Schweblin, Cécilia; Lambeng, Nathalie Dominique; Cherpillod, Pascal; Vazquez Antelo, Jessica; Lalive d'Epinay, Patrice; Schibler, Manuel; Delbouille-Naulot Deffert, Christine

doi:10.1093/cid/ciaa1165

Scientific article

English

Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients

ContributorsBellon, Mathilde Anne; Schweblin, Cécilia; Lambeng, Nathalie Dominique; Cherpillod, Pascal; Vazquez Antelo, Jessica; Lalive d'Epinay, Patrice; Schibler, Manuel; Delbouille-Naulot Deffert, Christine

Published inClinical infectious diseases, vol. 73, no. 9, p. e3102-e3105

Publication date2021-11-01

First online date2020-08-08

Abstract

This study analyzed the cerebrospinal fluid features of 31 coronavirus disease 2019 (COVID-19) patients with neurological complications. We observed neither severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the cerebrospinal fluid, nor intrathecal immunoglobulin G (IgG) synthesis but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis.

Keywords

COVID-19
SARS-CoV-2
Blood-brain barrier
Intrathecal synthesis
Neurological manifestations

Affiliation entities

Research groups

Citation (ISO format)

BELLON, Mathilde Anne et al. Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients. In: Clinical infectious diseases, 2021, vol. 73, n° 9, p. e3102–e3105. doi: 10.1093/cid/ciaa1165

Article (Published version)

OA OTHER

Supplemental data

Identifiers

PID : unige:155981
DOI : 10.1093/cid/ciaa1165
PMID : 32770235
PMCID : PMC7454353

Additional URL for this publicationhttps://academic.oup.com/cid/article/73/9/e3102/5890019

Journal ISSN1058-4838

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Creation03/11/2021 09:57:00

First validation03/11/2021 09:57:00

Update10/02/2026 08:13:20

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Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients

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