Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients

Article Article scientifique Article Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients eng 2020-08-08 2021-11-01 author Bellon Mathilde Anne 818960 author Schweblin Cécilia 808937 author Lambeng Nathalie Dominique 896660 author Cherpillod Pascal 650028 author Vazquez Antelo Jessica 774917 author Lalive d'Epinay Patrice 636926 author Schibler Manuel 96444 author Delbouille-Naulot Deffert Christine 639948 e3102-e3105 10.1093/cid/ciaa1165 32770235 1058-4838 PMC7454353 https://academic.oup.com/cid/article/73/9/e3102/5890019 This study analyzed the cerebrospinal fluid features of 31 coronavirus disease 2019 (COVID-19) patients with neurological complications. We observed neither severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in the cerebrospinal fluid, nor intrathecal immunoglobulin G (IgG) synthesis but did observe signs of blood-brain barrier disruption. These results might serve as a basis for a better understanding of SARS-CoV-2 related neuropathogenesis. COVID-19 SARS-CoV-2 Blood-brain barrier Intrathecal synthesis Neurological manifestations Dewey 616 Dewey 616.07 Dewey 616.8 137 Département de pathologie et immunologie 21F 56 Département de médecine 221 61 Département des neurosciences cliniques 226 false 505 Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale 843 400 Virologie clinique 668 1255 Virus émergents 993 Clinical infectious diseases 73 9 b907e878-70bc-4f0d-8b1a-8233b6109543 Article (Published version) Public ciaa1165.pdf 155492 application/pdf OA OTHER 87c491cb-e7c8-4a86-843b-6917cb0afa76 Supplemental data Public ciaa1165_suppl_supplementary_table.docx 22032 application/vnd.openxmlformats-officedocument.wordprocessingml.document openAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département des neurosciences cliniques

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Cerebrospinal Fluid Features in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reverse Transcription Polymerase Chain Reaction (RT-PCR) Positive Patients	Clinical infectious diseases			2021	253	267

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Vazquez Antelo, Jessica