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Scientific article
English

Detection of Na⁺ and K⁺ in the Rat Adrenal Cortex with the Electron Microprobe

Published inClinical science and molecular medicine, vol. 53, no. 5, p. 423-430
Publication date1977-11-01
Abstract

1. In order to demonstrate whether modification of aldosterone secretion is mediated by parallel changes of K⁺ in the adrenal zona glomerulosa, the total (intracellular + extracellular) Na⁺ and K⁺ content of the rat adrenal cortex was determined with the electron microprobe.

2. Groups of rats were submitted to one of the following dietary regimens: standard, low Na⁺, high K⁺ or high Na⁺.

3. Distribution of Na⁺ and K⁺ across the zona glomerulosa and zona fasciculata was compared. Standards of known electrolyte concentration were also analysed.

4. The [Na⁺] was found to be greater in the zona glomerulosa than in the zona fasciculata but K⁺ was distributed evenly in both zones. This was independent of dietary regimen.

5. Aldosterone production, assessed by plasma aldosterone concentrations, could not be correlated with zona glomerulosa K⁺ content.

eng
Keywords
  • Adrenal Cortex / analysis*
  • Aldosterone / blood
  • Animals
  • Corticosterone / blood
  • Electron Probe Microanalysis
  • Male
  • Potassium / analysis*
  • Rats
  • Sodium / analysis*
Citation (ISO format)
DECORZANT, Christiane et al. Detection of Na⁺ and K⁺ in the Rat Adrenal Cortex with the Electron Microprobe. In: Clinical science and molecular medicine, 1977, vol. 53, n° 5, p. 423–430. doi: 10.1042/cs0530423
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ISSN of the journal0301-0538
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