Detection of Na⁺ and K⁺ in the Rat Adrenal Cortex with the Electron Microprobe
|Published in||Clinical science and molecular medicine. 1977, vol. 53, no. 5, p. 423-430|
1. In order to demonstrate whether modification of aldosterone secretion is mediated by parallel changes of K⁺ in the adrenal zona glomerulosa, the total (intracellular + extracellular) Na⁺ and K⁺ content of the rat adrenal cortex was determined with the electron microprobe.
2. Groups of rats were submitted to one of the following dietary regimens: standard, low Na⁺, high K⁺ or high Na⁺.
3. Distribution of Na⁺ and K⁺ across the zona glomerulosa and zona fasciculata was compared. Standards of known electrolyte concentration were also analysed.
4. The [Na⁺] was found to be greater in the zona glomerulosa than in the zona fasciculata but K⁺ was distributed evenly in both zones. This was independent of dietary regimen.
5. Aldosterone production, assessed by plasma aldosterone concentrations, could not be correlated with zona glomerulosa K⁺ content.
|Keywords||Adrenal Cortex / analysis* — Aldosterone / blood — Animals — Corticosterone / blood — Electron Probe Microanalysis — Male — Potassium / analysis* — Rats — Sodium / analysis*|
Article (Published version) (3.8 MB) - Limited access to UNIGE
Other version: https://portlandpress.com/clinsci/article/53/5/423/70950/Detection-of-Na-and-K-in-the-Rat-Adrenal-Cortex
Faculté des sciences / Section des sciences de la Terre et de l'Environnement / Département des sciences de la Terre
|DECORZANT, Christiane et al. Detection of Na⁺ and K⁺ in the Rat Adrenal Cortex with the Electron Microprobe. In: Clinical science and molecular medicine, 1977, vol. 53, n° 5, p. 423-430. doi: 10.1042/cs0530423 https://archive-ouverte.unige.ch/unige:155807|