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Detection of Na⁺ and K⁺ in the Rat Adrenal Cortex with the Electron Microprobe

Decorzant, Christiane
Published in Clinical science and molecular medicine. 1977, vol. 53, no. 5, p. 423-430

1. In order to demonstrate whether modification of aldosterone secretion is mediated by parallel changes of K⁺ in the adrenal zona glomerulosa, the total (intracellular + extracellular) Na⁺ and K⁺ content of the rat adrenal cortex was determined with the electron microprobe.

2. Groups of rats were submitted to one of the following dietary regimens: standard, low Na⁺, high K⁺ or high Na⁺.

3. Distribution of Na⁺ and K⁺ across the zona glomerulosa and zona fasciculata was compared. Standards of known electrolyte concentration were also analysed.

4. The [Na⁺] was found to be greater in the zona glomerulosa than in the zona fasciculata but K⁺ was distributed evenly in both zones. This was independent of dietary regimen.

5. Aldosterone production, assessed by plasma aldosterone concentrations, could not be correlated with zona glomerulosa K⁺ content.

Keywords Adrenal Cortex / analysis*Aldosterone / bloodAnimalsCorticosterone / bloodElectron Probe MicroanalysisMalePotassium / analysis*RatsSodium / analysis*
PMID: 589927
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DECORZANT, Christiane et al. Detection of Na⁺ and K⁺ in the Rat Adrenal Cortex with the Electron Microprobe. In: Clinical science and molecular medicine, 1977, vol. 53, n° 5, p. 423-430. doi: 10.1042/cs0530423 https://archive-ouverte.unige.ch/unige:155807

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